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Evidence for the existence of 5‐hydroxytryptamine receptors, which are not of the 5‐HT 2 type, mediating contraction of rabbit isolated basilar artery
Author(s) -
Bradley P.B.,
Humphrey P.P.A.,
Williams R.H.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10149.x
Subject(s) - basilar artery , contraction (grammar) , receptor , 5 ht receptor , muscle contraction , serotonin , neuroscience , anatomy , endocrinology , medicine , biology
In the rabbit isolated basilar artery the contractile action of 5‐hydroxytryptamine (5‐HT) was little affected by high concentrations of ketanserin (1.0 × 10 −6 M) indicating that 5‐HT‐receptors other than those of the 5‐HT 2 ‐type were involved. The contractile action of 5‐HT was mimicked by methysergide and 5‐carboxamidotryptamine (5‐CT) with equipotent concentration ratios (5‐HT = 1) of about 22 and 0.6 respectively. This profile is characteristic of that in the dog saphenous vein which contains a 5‐HT receptor type that may be described as ‘5‐HT 1 ‐like’.