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The effect of α,β‐methylene ATP on the depolarization evoked by noradrenaline (γ‐adrenoceptor response) and ATP in the immature rat basilar artery
Author(s) -
Byrne N.G.,
Large W.A.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb09464.x
Subject(s) - basilar artery , adenosine triphosphate , adenosine , depolarization , chemistry , alpha (finance) , beta (programming language) , methylene blue , medicine , norepinephrine , endocrinology , biology , biochemistry , dopamine , surgery , construct validity , photocatalysis , computer science , patient satisfaction , programming language , catalysis
Depolarizations evoked by noradrenaline that were resistant to α‐ and β‐adrenoceptor antagonists were recorded in the rat basilar artery. These γ‐adrenoceptor‐mediated responses and the depolarizations to adenosine triphosphate (ATP) were blocked by pretreatment of the tissue with α,β‐methylene ATP. These data are discussed with respect to the selectivity of α,β‐methylene ATP.