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Antagonism of inhibitory amino acids by the steroid derivative RU5135
Author(s) -
Simmonds M.A.,
Turner J.P.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb16143.x
Subject(s) - cuneate nucleus , muscimol , picrotoxin , bicuculline , strychnine , gaba receptor antagonist , chemistry , antagonism , glycine , inhibitory postsynaptic potential , pharmacology , steroid , nucleus , antagonist , biochemistry , amino acid , biology , neuroscience , agonist , receptor , hormone
1 The steroid derivative RU5135 has been tested for its ability to antagonize glycine and the γ‐aminobutyric acid (GABA) analogue muscimol on isolated preparations of rat optic nerve and cuneate nucleus, respectively. 2 On the cuneate nucleus, RU5135 antagonized muscimol in a competitive manner with a pA 2 value of 8.31. RU5135 shared a common site of action with bicuculline that was separate from the Picrotoxin site. 3 On the optic nerve, RU5135 antagonized glycine with a pA 2 of 7.67. It shared a common site of action with strychnine.