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A pharmacological analysis of the responses of the gastrointestinal smooth muscle of the bat to transmural and periarterial nerve stimulation
Author(s) -
Cole Olatoun F.,
Marquis Victor O.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb16138.x
Subject(s) - tetrodotoxin , cholinergic , atropine , physostigmine , inhibitory postsynaptic potential , acetylcholine , excitatory postsynaptic potential , ileum , stimulation , medicine , endocrinology , hexamethonium , phentolamine , adrenergic , biology , bretylium , chemistry , receptor
1 A comparative study of the responses of the gastrointestinal tract of the guinea‐pig and of the fruit‐eating bat Eidolon helvum to transmural nerve stimulation (TNS) was made. 2 The stomach and rectum of the guinea‐pig, the bat and the guinea‐pig ileum contracted in response to TNS. These contractions were cholinergic in nature because atropine blocked and physostigmine potentiated them. 3 Tetrodotoxin reversibly abolished these contractions suggesting that they were nerve‐mediated. 4 The bat isolated ileum usually responded to TNS with mixed motor and inhibitory components. In some cases, there were only motor or inhibitory components. 5 The motor component was abolished by atropine and potentiated by physostigmine. However, the inhibitory component was non‐adrenergic and non‐cholinergic (NANC). 6 Tetrodotoxin abolished the motor component without influencing the inhibitory component. 7 Periarterial nerve stimulation of the bat ileum produced a relaxation that was blocked by bretylium, propranolol, phentolamine, reserpine and tetrodotoxin. 8 It is concluded that the bat gastrointestinal smooth muscle, like the guinea‐pig, has cholinergic excitatory innervation; however, the bat ileum has both a cholinergic excitatory innervation and a non‐adrenergic and non‐cholinergic inhibitory component.