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Interference of sodium with [ 3 H]‐nitrendipine binding to cardiac membranes
Author(s) -
Schwartz Jean,
Velly Jeanne
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb12935.x
Subject(s) - nitrendipine , sodium , chemistry , membrane , skeletal muscle , binding site , ventricle , cardiac muscle , guinea pig , endocrinology , medicine , biology , biochemistry , calcium , organic chemistry
1 Interference of sodium with [ 3 H]‐nitrendipine binding was studied on membrane homogenates from guinea‐pig skeletal muscle, cerebral cortex and left cardiac ventricle. 2 [ 3 H]‐nitrendipine binding on homogenates from cerebral cortex and skeletal muscle was unaffected by Na + (35 and 140 mEql −1 ). 3 On the other hand, for the myocardial receptors, addition of Na + resulted in an increase in IC 50 of nitrendipine. 4 Simultaneously, for the myocardial preparations, saturation curves showed a decrease in [ 3 H]‐nitrendipine affinity and an increase in the number of binding sites.