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Comparison of the action of cholinomimetics and pentagastrin on gastric secretion in dogs
Author(s) -
Magee D.F.,
Naruse S.,
Pap A.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb12919.x
Subject(s) - pentagastrin , medicine , endocrinology , pepsin , gastric acid , gastrin , stimulation , secretion , methacholine , stomach , cholecystokinin , atropine , chemistry , biochemistry , respiratory disease , receptor , lung , enzyme
1 Stimulation of acid secretion by muscarinic cholinomimetic agents depended on the periodic interdigestive activity of the stomach. This explains the peak and following fade. 2 Pentagastrin stimulated gastric secretion after a fixed interval and did not depend on the interdigestive activity. 3 Neither gastrin nor methacholine directly contracted the gallbladder in the doses used. 4 A sustained secretion of gastric acid and pepsin, such as follows a meal, required both hormonal stimulation and gastric distension. 5 The magnitude of the acid response from Heidenhain pouches following meals suggested that pentagastrin doses commonly used experimentally greatly exceed the physiological.