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Effects of chronic administration of amitriptyline or mianserin on rat cardiac and central adrenoceptors
Author(s) -
Choudhury L.,
O'Donnell J.M.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb10558.x
Subject(s) - mianserin , amitriptyline , hippocampus , endocrinology , receptor , cerebral cortex , medicine , alpha (finance) , pharmacology , anesthesia , chemistry , antidepressant , surgery , construct validity , patient satisfaction
1 Rats were administered either amitriptyline (20 mg kg −1 , i.p.) or mianserin (10 mg kg −1 , i.p.) for 21 consecutive days and the α‐ and β‐adrenoceptor characteristics of cardiac ventricles, cerebral cortex and hippocampus examined by ligand‐binding procedure. 2 Chronic administration of amitriptyline significantly reduced the maximum density of β‐receptors in the cerebral cortex without significantly altering cardiac α‐ or β‐receptors; mianserin treatment had no significant effect on any of the receptors studied.