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The effect of reserpine treatment on the extraneuronal uptake of [ 3 H]‐isoprenaline into rat atria
Author(s) -
Morton A.J.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb09460.x
Subject(s) - isoprenaline , reserpine , medicine , chemistry , endocrinology , stimulation
1 Treatment of rats with reserpine (1 mg kg −1 day −1 ) for up to 7 days resulted in a marked decrease in a corticosterone‐sensitive component of the extraneuronal accumulation of [ 3 H]‐isoprenaline into their atria. 2 The change in extraneuronal uptake did not appear to be due to a direct action of reserpine on the uptake mechanism, since it was several days before the treatment had a significant effect on the accumulation of [ 3 H]‐isoprenaline. Further, reserpine in vitro did not inhibit extraneuronal uptake. 3 The reserpine‐induced change in the accumulation of [ 3 H]‐isoprenaline was not an artifact due to changes in water balance, ion distribution, extracellular space or tissue atrophy. Nor was the change due to an increase in the efflux of [ 3 H]‐isoprenaline from the tissue. 4 These experiments support the suggestion that the extraneuronal uptake is dependent upon a functional adrenergic innervation.