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Kinin effects on ion transport in monolayers of HCA‐7 cells, a line from a human colonic adenocarcinoma
Author(s) -
Cuthbert A.W.,
Kirkland Susan C.,
MacVinish Lesley J.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb09428.x
Subject(s) - kinin , monolayer , adenocarcinoma , chemistry , receptor , epithelial polarity , microbiology and biotechnology , cell culture , membrane , biophysics , endocrinology , medicine , biology , biochemistry , bradykinin , cancer , genetics
Using epithelial monolayers of HCA‐7 cells, derived from a primary human colonic adenocarcinoma and grown on pervious supports, it is shown that responses to lysylbradykinin can be elicited from either side. It is proposed that kinin receptors are inserted into both apical and basolateral membrane domains.