Premium
The effects of methyl β‐carboline‐3‐carboxylate on social interaction and locomotor activity when microinjected into the nucleus raphé dorsalis of the rat
Author(s) -
Hindley S.W.,
Hobbs A.,
Paterson I.A.,
Roberts M.H.T.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08955.x
Subject(s) - microinjections , anxiogenic , intraperitoneal injection , chemistry , endocrinology , medicine , neuroscience , pharmacology , psychology , central nervous system , biology , receptor , biochemistry , anxiolytic
1 Intraperitoneal and intracerebral injections of methyl β‐carboline‐3‐carboxylate (βCCM) and intracerebral injections of RO 15–1788 were given to rats. The performance of the rats in the social interaction test was measured to determine if changes in social interaction induced by βCCM were mediated in part by the nucleus raphé dorsalis (NRD). 2 Intraperitoneal injections of βCCM, 2 and 4 mg kg −1 , reduced social interaction. 3 Intracerebral microinjections of βCCM (10‐0.1 ng in 0.5 μl) into the NRD reduced social interaction. Injections outside the NRD did not have this effect. 4 Intracerebral microinjections of RO 15–1788 (1 ng in 0.5 μl) into the NRD had no effect when given alone, but blocked the reduction in social interaction caused by intracerebral or intraperitoneal injections of βCCM. 5 No effect was observed when R 15–1788 was microinjected into sites outside the NRD. 6 Changes in social interaction may reflect changes in anxiety. The NRD may be one of the important sites for the expression of the anxiogenic actions of βCCM.