Premium
The effects of the protease inhibitor, aprotinin, on the course of shock induced by endotoxin in cats
Author(s) -
Hughes B.,
Parratt J.R.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08909.x
Subject(s) - aprotinin , cats , protease inhibitor (pharmacology) , medicine , protease , pharmacology , shock (circulatory) , anesthesia , chemistry , immunology , biochemistry , enzyme , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy
1 The administration of endotoxin derived from Escherichia coli to anaesthetized cats resulted, within the first 5 min, in an initial increase in right atrial pressure and a reduction in systemic arterial blood pressure. Over the next 2 h shock was characterized by a reduced cardiac output, tachycardia, reduced arterial pH and an increased level of lactate. The survival rate at the end of the 8 h experimental period was only 10%. 2 The protease inhibitor aprotinin (Trasylol), given as a continuous intravenous infusion 1000 kallikrein inhibitor units (k.i.u.) kg −1 h −1 together with a bolus of 40,000 k.i.u. kg −1 , significantly inhibited the severity and incidence of the initial endotoxin response (increase in right atrial pressure and systemic hypotension), perhaps suggesting the direct or indirect involvement of kinins. 3 Aprotinin did not reduce the delayed effects of endotoxin (sustained reduction in cardiac output, lacticacidosis), nor did it improve survival at 8 h. Indeed, there was some evidence that aprotinin exaggerated the delayed effects of endotoxin in this model.