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The effects of chemical sympathectomy on dopamine, noradrenaline and adrenaline content in some peripheral tissues
Author(s) -
Caramona M.M.,
SoaresdaSilva P.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08903.x
Subject(s) - pargyline , endocrinology , medicine , dopamine , chemistry , adrenal medulla , norepinephrine , catecholamine , renal artery , kidney , serotonin , receptor
1 Dopamine, noradrenaline (NA) and adrenaline (Ad) depletion by 6‐hydroxydopamine (6‐OHDA) and pargyline plus 6‐OHDA was investigated in the cat left ventricle, mesenteric and renal arteries, renal cortex, renal medulla and adrenal medulla. Catecholamine concentrations in plasma were also analyzed in these two experimental conditions. 2 6‐OHDA alone or in combination with pargyline induced parallel decreases of NA and dopamine contents in the left ventricle. In the main trunk and proximal branches of the mesenteric artery and renal artery 6‐OHDA selectively reduced NA without a parallel decrease in dopamine content. Previous treatment with pargyline abolished this selectivity. 3 In the kidney of control animals, dopamine content was greater than could be attributed to its presence only in noradrenergic neurones. In the renal cortex 6‐OHDA reduced significantly dopamine and NA contents, and in the renal medulla only NA levels were decreased by this drug. Pargyline plus 6‐OHDA did not deplete the NA content either in the renal cortex or in the renal medulla, and only reduced significantly the dopamine content in the renal cortex. 4 NA concentrations in plasma were increased by pargyline plus 6‐OHDA whilst Ad remained unaffected. In the adrenal medulla only NA content was reduced either by 6‐OHDA or pargyline plus 6‐OHDA. 5 The present findings suggest a NA‐independent dopamine pool in both segments of the mesenteric artery and renal artery but not in the left ventricle.