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Theophylline‐sensitive modulation of non‐cholinergic excitatory neurotransmission in the guinea‐pig ileum
Author(s) -
Barthó L.,
Pethö G.,
Rónai Z.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08898.x
Subject(s) - theophylline , excitatory postsynaptic potential , adenosine , inhibitory postsynaptic potential , cholinergic , acetylcholine , medicine , neurotransmission , atropine , endocrinology , chemistry , ileum , guinea pig , pharmacology , biology , receptor
Atropine‐resistant longitudinal contractions of the guinea‐pig ileum due to field stimulation were greatly augmented by theophylline (150 μM). Adenosine exerted an opposite effect. Theophylline did not potentiate contractions evoked by exogenous substance P. It is suggested that a theophylline‐sensitive inhibitory mechanism (possibly mediated by adenosine or a related substance) controls transmitter release from enteric non‐cholinergic excitatory neurones.