Premium
The effects of the combined administration of β‐adrenoceptor antagonists and non‐steroidal anti‐inflammatory drugs on ligation‐induced arrhythmias in rats
Author(s) -
Fagbemi O.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08869.x
Subject(s) - ligation , medicine , pharmacology , anti arrhythmia agents , beta adrenoceptor , adrenergic receptor , anesthesia , receptor , atrial fibrillation
1 Pretreatment of anaesthetized rats with intravenously administered β‐adrenoceptor antagonists or non‐steroidal anti‐inflammatory drugs (NSAIDs) reduced the incidence and severity of ventricular arrhythmia which resulted from acute coronary artery ligation. 2 The β‐adrenoceptor antagonists preferentially suppressed the immediate (Phase 1A) arrhythmia while the NSAIDs suppressed the delayed (Phase IB) arrhythmias. 3 Combined administration of β‐adrenoceptor antagonists and the NSAIDs produced a more pronounced antiarrhythmic effect than either of the drugs alone.