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Inhibitory effects of forskolin and papaverine on nerve conduction partially blocked by tetrodotoxin in the frog sciatic nerve
Author(s) -
Ribeiro J.A.,
Sebastião A.M.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08861.x
Subject(s) - tetrodotoxin , papaverine , forskolin , chemistry , sodium channel , compound muscle action potential , sciatic nerve , biophysics , sodium , electrophysiology , endocrinology , pharmacology , anatomy , medicine , biochemistry , biology , receptor , organic chemistry
1 The effects of forskolin, sodium fluoride and papaverine on compound action potentials were investigated in de‐sheathed sciatic nerve preparations of the frog. 2 Forskolin decreased in a concentration‐dependent manner the amplitude of compound action potentials when nerve conduction was partially blocked by tetrodotoxin (TTX). In the presence of TTX a 50% decrease in the action potential amplitude recorded was obtained with about 2.5 μM forskolin. 3 Sodium fluoride did not modify the amplitude of compound action potentials partially blocked by TTX. 4 Papaverine also decreased the amplitude of compound action potentials partially inhibited by TTX. A 50% decrease in the action potential amplitude recorded in the presence of TTX was obtained with about 10 μM papaverine. 5 The possibility that cyclic AMP modulates axonal excitability by interfering with the entry of sodium through the TTX‐sensitive sodium channel is discussed.