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Similarity between μ‐opioid receptors in mouse vas deferens and guinea‐pig ileum
Author(s) -
Goodall Jacqueline,
Hughes I.E.,
Mackay D.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08857.x
Subject(s) - vas deferens , ileum , agonist , (+) naloxone , receptor , endocrinology , medicine , guinea pig , opioid , chemistry , pharmacology , opioid receptor , biology
1 The effects of the opioid receptor agonist RX783006 and of the opioid receptor partial agonist (+)‐meptazinol have been examined on electrically‐induced twitch responses of the guinea‐pig isolated ileum and of the mouse isolated vas deferens. 2 Log 10 concentration‐tissue state curves were determined for (+)‐meptazinol and for RX783006, alone, in combination and, when appropriate, in the presence of naloxone (30 nM). 3 Analysis of these log 10 concentration‐tissue state curves using the null equations derived and verified in the previous paper allows quantitation of the characteristics of the interaction of (+)‐meptazinol with the opioid receptors in these tissues. 4 The results indicate that the apparent differences in the actions of (+)‐meptazinol on isolated electrically‐stimulated guinea‐pig ileum and mouse vas deferens can be accounted for without the need to postulate differences between μ‐opioid receptors in these two tissues.