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Role of putative neurotransmitters in the central gastric antisecretory effect of prostaglandin E 2 in rats
Author(s) -
Puurunen Juhani
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08849.x
Subject(s) - medicine , endocrinology , phentolamine , idazoxan , chemistry , sulpiride , histaminergic , histamine , dopamine , prazosin , receptor , biology , dopaminergic , antagonist
1 The role of putative neurotransmitters of the central nervous system in the central gastric antisecretory effect of prostaglandin E 2 (PGE 2 ) was investigated in pylorus‐ligated rats. 2 Pretreatment of the rats with an intracerebroventricular (i.c.v.) injection of 6‐hydroxydopamine (6‐OHDA) prevented the antisecretory effect of the i.c.v. administration of PGE 2 , whereas pretreatment with 5,6‐dihydroxytryptamine (5,6‐DHT) plus p ‐chlorophenylalanine (PCPA) had no effect. 3 I.c.v.‐administered phentolamine and idazoxan antagonized the inhibition of gastric secretion induced by i.c.v. PGE 2 , whereas prazosin, propranolol and sulpiride injected via the same route were ineffective. 4 Diphenhydramine, cimetidine, naloxone and theophylline, all administered i.c.v., did not modify the antisecretory effect of i.c.v. PGE 2 . 5 The results suggest that an activation of α 2 ‐adrenoceptors in the brain is involved in the central gastric antisecretory effect of PGE 2 , whereas neither central 5‐hydroxytryptamine receptors, α 1 ‐ or β‐adrenoceptors, D 2 ‐dopamine receptors, histamine or opioid receptors nor adenosine seem to play any role here.