Premium
Forskolin: its effects on potassium‐evoked release of vasopressin from the rat neurohypophysis
Author(s) -
Bowman David,
Hope Derek B.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08847.x
Subject(s) - forskolin , vasopressin , potassium , endocrinology , chemistry , medicine , potassium channel , neuroscience , biology , stimulation , organic chemistry
1 The effect of forskolin, added either before or 5 min after the onset of potassium‐evoked release of vasopressin from isolated neurointermediate lobes of the rat has been investigated. 2 A low concentration of forskolin (1 μM), added before stimulation, enhanced the potassium‐evoked release of vasopressin throughout two successive 5 min periods of stimulation. Higher concentrations of forskolin (10–80 μM) produced no effect on the potassium‐evoked release of hormone during the first 5 min of stimulation, but inhibited release during the second 5 min period. 3 When added 5 min after the onset of potassium stimulation, forskolin (1–80 μM) reduced the amount of vasopressin released during the remaining 5 min of stimulation. 4 Forskolin produced a concentration‐dependent increase in cyclic AMP during both the control and potassium stimulation periods. 5 The amount of cyclic AMP generated by forskolin during potassium stimulation was less than that produced during the corresponding control periods.