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Synergistic interaction between histamine and ouabain on ventricular fibrillation threshold
Author(s) -
Trzeciakowski Jerome P.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08826.x
Subject(s) - histamine , ouabain , cimetidine , ventricular fibrillation , mepyramine , antagonist , fibrillation , ed50 , pharmacology , histamine h2 receptor , pyrilamine , chemistry , medicine , endocrinology , receptor , atrial fibrillation , sodium , organic chemistry
1 The interaction between histamine and ouabain on the ventricular fibrillation threshold (VFT) was studied in the isolated, Langendorff‐perfused heart of the guinea‐pig. 2 When administered separately, histamine and ouabain each reduced the VFT in a concentration‐related manner with ED 50 values of 84.3 and 250 nM, respectively. 3 When perfused in combination the effects of these two drugs on VFT were significantly greater than the sum of their individual contributions. 4 Mepyramine and cimetidine both antagonized the fibrillatory effects of the histamine‐ouabain combination. Neither antagonist affected the fibrillation concentration‐response curve for ouabain. 5 These results suggest that both classes of histamine receptor may participate in the histamine‐ouabain interaction.