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Reduction of urinary excretion of PGE 2 and 6 keto PGF 1α by tiaprofenic acid
Author(s) -
Lote C. J.,
McVicar A.J.,
Thewles A.
Publication year - 1985
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1985.tb08824.x
Subject(s) - excretion , diuretic , endocrinology , medicine , chemistry , alpha (finance) , urinary system , body weight , prostaglandin e , urine , prostaglandin , surgery , construct validity , patient satisfaction
1 Tiaprofenic acid (Surgam, Cassenne) was administered intravenously to saline‐diuretic conscious rats, at doses of 2, 10 and 25 mg kg −1 body weight. 2 Tiaprofenic acid significantly reduced urinary prostaglandin E 2 (PGE 2 ) and 6 keto PGF 1α excretion, at all three doses employed. The extent of the reduction was similar for both PGE 2 and 6 keto PGF 1α output; hence no evidence of ‘selectivity’ (i.e. sparing of PGI 2 synthesis) was observed. 3 Tiaprofenic acid was also administered to rats receiving an infusion of 5% dextrose. The dose employed (0.5 or 1 mg kg −1 body weight) was submaximal and elicited reductions in PGE 2 output to values still more than 60% of the control period values. In this group of animals, the percentage change in 6 keto PGF 1α excretion was again not significantly different from that of PGE 2 . 4 The maximal extent of reduction in urinary PGE 2 excretion with tiaprofenic acid (25 mg kg −1 body weight) was not significantly different from that elicited by indomethacin (10 mg kg −1 body weight), although the time course of the reduction was different.