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Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea‐pig
Author(s) -
Fryer Allison D.,
Maclagan Jennifer
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb16539.x
Subject(s) - bronchoconstriction , muscarinic acetylcholine receptor , gallamine triethiodide , acetylcholine , pilocarpine , chemistry , endocrinology , medicine , muscarinic acetylcholine receptor m1 , guanethidine , atropine , muscarinic acetylcholine receptor m4 , vagus nerve , muscarinic acetylcholine receptor m2 , stimulation , receptor , psychiatry , asthma , epilepsy
1 In anaesthetized guinea‐pigs, gallamine produced a dose‐related potentiation of the bronchoconstriction induced by electrical stimulation of the cervical vagus nerves; (+)‐tubocurarine and suxamethonium lacked this effect. 2 The bronchoconstriction produced by intravenous injection of acetylcholine or histamine, however, was not potentiated by gallamine. 3 Vagally‐induced bradycardia was abolished by gallamine, confirming antagonism of the effect of acetylcholine on muscarinic receptors in the heart. 4 The muscarinic receptor agonist pilocarpine, had the opposite effect to gallamine in the lung as it inhibited vagally‐mediated bronchoconstriction. 5 Pretreatment of guinea‐pigs with either guanethidine or propranolol did not affect the gallamine‐induced potentiation of vagally‐mediated bronchoconstriction. 6 The potentiating effect of gallamine in the lung can be explained by blockade of inhibitory, muscarinic receptors located in the parasympathetic nerves supplying the lungs.