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Purine involvement in morphine antinociception
Author(s) -
Mantegazza Paolo,
Tammiso Remigio,
Zambotti Fernanda,
Zecca Luigi,
Zonta Nerina
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb16527.x
Subject(s) - morphine , adenosine , caffeine , chemistry , pharmacology , endocrinology , adenylate kinase , medicine , receptor , biochemistry
1 The effects of a series of adenosine derivatives on morphine antinoceptive effect were investigated in rats by the ‘tail‐flick’ method. 2 2‐Chloroadenosine (CADO) and L ‐N 6 ‐phenylisopropyladenosine ( L ‐PIA), given intraperitoneally, caused decreased morphine antinociception. 3 Intracerebroventricular injections of CADO, L ‐PIA and 5′‐N‐ethylcarboxamide adenosine (NECA), but not of 2′‐deoxyadenosine, antagonized morphine antinociception. 4 The effects of both central and peripheral injections of CADO and L ‐PIA on morphine antinociception were partially reversed by caffeine. 5 Intracerebroventricular injection of dibutyryl‐cyclic 3′,5′ adenosine monophosphate (db cyclic AMP) had no effect on morphine antinociception. 6 These data indicate that adenosine plays a role in morphine‐induced antinociception. The results are discussed in terms of postulated effects of adenosine derivatives on adenylate cyclase.