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α 2 ‐Adrenoceptor agonists potentiate responses mediated by α 1 ‐adrenoceptors in the cat nictitating membrane
Author(s) -
Shepperson N.B.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb16508.x
Subject(s) - nictitating membrane , adrenergic receptor , endocrinology , medicine , adrenergic , chemistry , receptor , pharmacology , mathematics , statistics , classical conditioning , conditioning
1 α 1 but not α 2 ‐adrenoceptors mediate contractions of the cat nictitating membrane. 2 The contractions of this tissue evoked by α 1 ‐adrenoceptor agonists, but not those evoked by angiotensin II, are potentiated by pre‐dosing with α 2 ‐adrenoceptor agonists. 3 This potentiation is reversed by the α 2 ‐adrenoceptor antagonist, WY 2639. 4 Pressor responses evoked by α 1 ‐adrenoceptor agonists or angiotensin II were not affected by α 2 ‐adrenoceptor agonists. 5 Contractions of the nictitating membrane evoked by noradrenaline were reduced by pretreatment with WY 2639. 6 These results suggest that in some tissues the role of α 2 ‐ adrenoceptors may be to modulate responses to α 1 ‐adrenoceptors, rather than to evoke a discrete response themselves.