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Cardiovascular studies with SK&F 93319, an antagonist of histamine at both H 1 ‐ and H 2 ‐receptors
Author(s) -
Harvey Carol A.,
Owen D.A.A.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb16503.x
Subject(s) - histamine , dimaprit , antagonist , histamine h2 receptor , medicine , chemistry , endocrinology , receptor antagonist , pharmacology , receptor
1 Cardiovascular studies have been made in anaesthetized cats with SK&F 93319, an antagonist of histamine at both H 1 ‐ and H 2 ‐receptors. 2 SK&F 93319, 8 × 10 −8 and 4 × 10 −7 mol kg −1 min −1 antagonized depressor responses to injections of histamine and the maximum displacement of histamine dose‐response curves exceeded that which can be obtained with either an H 1 ‐receptor antagonist or an H 2 ‐receptor antagonist alone. 3 SK&F 93319, 8 × 10 −8 and 4 × 10 −7 mol kg −1 min −1 , also caused dose‐dependent antagonism of histamine‐induced falls in blood pressure and total peripheral resistance during intravenous infusions of histamine. 4 SK&F 93319 inhibited depressor responses to intravenous injections of 2‐(2‐aminoethyl)pyridine, dimaprit and impromidine. The displacement of the 2‐(2‐aminoethyl)pyridine dose‐response curve was similar to the displacement of histamine dose‐response curves. SK&F 93319 caused greater displacement of dimaprit or impromidine dose‐response curves than of histamine or 2‐(2‐aminoethyl)pyridine dose‐response curves. 5 SK&F 93319 was an effective antagonist of histamine, 2‐(2‐aminoethyl)pyridine or dimaprit‐induced vasodilatation in femoral and gastric vasculature. 6 SK&F 93319 has been shown to be an effective antagonist of vascular responses to histamine in anaesthetized cats. SK&F 93319 appeared to be more effective as an H 2 ‐receptor antagonist than as an H 1 ‐receptor antagonist in these vascular studies.