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Effect of pertussis toxin on normorphine‐dependence and on acute inhibitory effects of normorphine and clonidine in guinea‐pig isolated ileum
Author(s) -
Tucker J.F.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb16491.x
Subject(s) - ileum , guinea pig , inhibitory postsynaptic potential , pertussis toxin , clonidine , pharmacology , biology , chemistry , medicine , g protein , receptor
In guinea‐pig isolated ileum from animals pretreated with Pertussis toxin, the acute inhibitory effects of normorphine and clonidine on electrically induced contractions were markedly attenuated whilst responses to acetylcholine and electrical stimulation were unaltered. Pertussis toxin treatment also reduced naloxone‐precipitated withdrawal contractures in normorphine‐dependent tissues. These results suggest that the acute and chronic effects of normorphine are mediated by the same mechanism, namely that of adenylate cyclase inhibition.