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Regional differences in the response to vasoconstrictor agents of dog and monkey isolated coronary arteries
Author(s) -
Miwa Kunihisa,
Toda Noboru
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb16471.x
Subject(s) - vasoconstrictor agents , coronary arteries , cardiology , medicine , vasoconstriction , artery
1 Contractile responses to vasoconstrictor agents were compared in helical strips of dog and monkey epicardial coronary arteries of different sizes. Contractions of large, medium and small arteries induced by KCl (30m M ) were virtually identical. 2 Contractions induced by 5‐hydroxytryptamine (5‐HT) (10 −9 ‐2 × 10 −6 M ) were in the order of large > medium > small arteries in dogs, and large = medium > small arteries in monkeys. Cinanserin suppressed these responses. 3 In contrast, contractions produced by angiotensin II (AII) (10 −7 M ) were in the order of small > medium > large arteries in dogs, and small > medium = large arteries in monkeys. Sar 1 ‐Ala 8 ‐angiotensin II markedly attenuated the peptide‐induced contractions. 4 Contractions induced by prostaglandin F 2α (PGF 2α ) were significantly greater in large and medium sized arteries than in small arteries in dogs, while those of the arteries of different sizes isolated from monkeys did not differ. Contractions induced by carbocyclic thromboxane A 2 (c‐TXA 2 ), in arteries of different sizes in dogs and monkeys, did not differ. 5 These results suggest that the sensitivity and/or the population of 5‐HT receptors are greater in proximal coronary arteries than in distal arteries, while, in contrast, the sensitivity and/or population of AII receptors are greater in distal coronary arteries. Receptors for PGF 2α and c‐TXA 2 appear to react to a similar degree in monkey arteries of different sizes, although receptors for PGF 2α appear to be fewer in distal coronary arteries in dogs.