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Prostaglandins and thromboxane in the delayed phase of shock induced by Serratia marcescens endotoxin
Author(s) -
Parratt J.R.,
Sharma N.,
Zeitlin I.J.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb16469.x
Subject(s) - medicine , prostacyclin , endocrinology , blood pressure , shock (circulatory) , thromboxane b2 , vasoconstriction , thromboxane a2 , mean arterial pressure , anesthesia , heart rate , platelet
1 The cardiovascular and metabolic effects of an endotoxin derived from Serratia marcescens were examined in anaesthetized, spontaneously‐breathing cats. There was a marked initial elevation of right atrial pressure (the result of pulmonary vasoconstriction) and decreases in systemic arterial pressure and in arterial P O2 . 2 The ‘delayed’ effects of endotoxin shock in this species (1–8 h) consisted of a reduced cardiac output and decreased urinary excretion. Blood pressure and myocardial contractility (assessed from measurement of left ventricular (LV) dP/dt and LV end‐diastolic pressure) were maintained throughout this phase. There was evidence of a metabolic (lactic) acidosis largely compensated by hyperventilation. 3 Plasma levels (both arterial and mixed venous blood samples) of prostaglandin (PG)E 2 , PGF 2α , 6‐keto PGF 1α and thromboxane (TX)B 2 were measured by radioimmunoassay techniques. Endotoxin administration caused substantial increases in the plasma levels of all four derivatives of arachidonic acid, especially between 1 and 6 h. 4 Separation of the endotoxin‐treated cats into survivors and non‐survivors showed that the non‐survivors had significantly higher circulating levels of PGE 2 , TXB 2 and PGF 2α . It is suggested that TXB 2 and PGF 2α might contribute to some of the detrimental effects of endotoxin (e.g. pulmonary, mesenteric, renal vasoconstriction; platelet aggregation with resulting organ failure) and that prostacyclin may be beneficial in endotoxin shock in this species.