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Prazosin inhibits small intestinal transit in the rat
Author(s) -
Rush B.D.,
Ruwart M.J.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10792.x
Subject(s) - gastric emptying , transit (satellite) , medicine , prazosin , transit time , gastrointestinal transit , gastroenterology , endocrinology , chemistry , stomach , antagonist , receptor , public transport , political science , transport engineering , law , engineering
Gastric emptying, small intestinal transit, and colonic transit were measured in fasted rats preimplanted with either duodenal or colonic cannulae. At the doses stated, prazosin (given subcutaneously) had no effect on gastric emptying or colonic transit, whereas small intestinal transit was significantly delayed.
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