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Effect of muscarinic ligands on the electrical activity recorded from the hippocampus: a quantitative approach
Author(s) -
Bevan Paul
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10778.x
Subject(s) - muscarinic acetylcholine receptor , hippocampus , halothane , chemistry , electrophysiology , endocrinology , acetylcholine , medicine , neuroscience , receptor , biology , biochemistry , organic chemistry
1 The electrical activity of the hippocampus was recorded from the CA 1 region in rats anaesthetized with halothane and the effects of compounds assessed following their intravenous injection. Quantification of the effects was achieved following on‐line fast Fourier transformation of the signal. 2 The electrical activity recorded from the hippocampus of the halothane‐anaesthetized rat demonstrated identical characteristics to that recorded from the freely‐moving animal. 3 Three types of activity could be distinguished: rhythmical slow wave activity (RSA or theta); large amplitude slow wave activity (LIA); and small amplitude fast wave activity. 4 Muscarinic agonists induced RSA with a consequent reduction in power. The effects were dose‐dependent and were reversibly antagonized by scopolamine, but not methyl‐scopolamine, indicating that the effects are mediated centrally by muscarinic receptors. 5 The results show that, in halothane anaesthetized rats, a muscarinic RSA occurs which is unrelated to movement or behavioural arousal.