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Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization
Author(s) -
Moochhala S.M.,
Sawynok J.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10773.x
Subject(s) - eledoisin , desensitization (medicine) , substance p , hyperalgesia , nociception , pharmacology , chemistry , receptor , medicine , potency , endocrinology , neuropeptide , in vitro , biochemistry
1 The hyperalgesic effect of intrathecally administered substance P (SP), physalaemin, eledoisin and eledoisin‐related peptide (ERP) was investigated in the rat tail flick test. 2 Hyperalgesia produced by SP (2.5–15 μg, 1.9–11 nmol) was maximal 10–20 min after injection, lasted 30 min and was dose‐related. The effect was mimicked by all of the peptides examined. The rank order of potency was physalaemin > SP > eledoisin > ERP. 3 Desensitization to the hyperalgesic effect of SP was produced by three repeated intrathecal injections. Rats desensitized to SP no longer responded to physalaemin or ERP, indicating cross‐desensitization. Phentolamine continued to produce hyperalgesia following such desensitization. 4 The demonstration of a hyperalgesic effect for SP provides further support for a role for SP in nociceptive transmission. The receptor mediating this effect appears to be a SP‐P subtype. Cross‐desensitization between peptides suggests an action on the same receptor.