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Effects of phosphorothioate analogues of ATP, ADP and AMP on guinea‐pig taenia coli and urinary bladder
Author(s) -
Burnstock G.,
Cusack N.J.,
Meldrum L. A.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10771.x
Subject(s) - diastereomer , taenia coli , stereoselectivity , guinea pig , purinergic receptor , chemistry , taenia , stereochemistry , biology , biochemistry , endocrinology , immunology , receptor , helminths , catalysis
1 Phosphorothioate analogues of ATP, ADP and AMP were tested on the guinea‐pig taenia coli and urinary bladder. 2 The R p diastereoisomers of the phosphorothioate analogues, ATP‐α‐S and ADP‐α‐S were respectively 7 and 3 times more effective than the Sp diastereoisomers in causing relaxation of the taenia coli. No stereoselectivity was observed for the diastereoisomers of ATP‐β‐S. 3 In guinea‐pig bladder, no stereoselectivity was observed for any of the phosphorothioate analogues. 4 These results show that P 2 ‐purinoceptors mediating inhibitory responses in the guinea‐pig taenia coli show marked stereoselectivity, while P 2 ‐purinoceptors mediating excitatory responses in the guinea‐pig bladder show little stereoselectivity.