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The effects of 3,5,5‐trimethylcyclohexanol on hepatic cholesterol synthesis, bile flow and biliary lipid secretion in the rat
Author(s) -
Bell G.D.,
Clegg R.J.,
Ellis W.R.,
Middleton B.,
White D.A.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10759.x
Subject(s) - choleretic , cholesterol , medicine , secretion , endocrinology , chemistry , bile acid , reductase , biology , biochemistry , enzyme
1 The chemical trimethylcyclohexanol (TMC) is closely related to menthol, the major component of a terpene preparation with known choleretic and cholelitholytic activity. Its effects on hepatic cholesterol synthesis and bile secretion were examined in the rat. 2 In both acute and long‐term dosing experiments TMC significantly inhibited hepatic S‐3‐hydroxy‐3‐methylglutaryl coenzyme A (HMGCoA) reductase. TMC was a potent choleretic, with detectable effects on bile flow at low doses, which also reduced coupling of cholesterol secretion to bile salt secretion. Single large doses tended to lower biliary cholesterol output and caused significant reduction in cholesterol saturation index after biliary diversion for 1h. 3 TMC and its widely prescribed ester cyclandelate, which is rapidly degraded to TMC after ingestion, should be investigated further as potential cholelitholytic treatments in man.