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Wash‐out of noradrenaline and its metabolites by calcium‐free reperfusion after ischaemia: support for the concept of ischaemia‐induced noradrenaline release
Author(s) -
Abrahamsson T.,
Almgren O.,
Carlsson L.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10738.x
Subject(s) - ischemia , calcium , myocardial ischaemia , medicine , chemistry , norepinephrine , anesthesia , endocrinology , pharmacology , dopamine
The outflow of noradrenaline (NA) and its metabolites on reperfusion after 60 min of regional ischaemia in the isolated heart of the rat was not diminished when calcium was omitted from the reperfusion medium. The findings suggest a release of NA during ischaemia, washed‐out at reperfusion.