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The effect of prostaglandin D 2 on the blood vessels of the perfused isolated cotyledon of the human placenta
Author(s) -
Abramovich D. R.,
Page K.R.,
Parkin A.M.L.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10737.x
Subject(s) - placenta , prostaglandin , in utero , cotyledon , blood vessel , endocrinology , blood flow , medicine , chemistry , biology , pregnancy , fetus , botany , genetics
Prostaglandin D 2 was shown to constrict the blood vessels of the isolated perfused cotyledon of the human placenta. Its potency was less than that of prostaglandin F 2α but similar to prostaglandin E 2 . As it is known to dilate uterine blood vessels it may, by its differential action on the foetal and maternal vascular beds, play a role in the local regulation of utero‐placental blood flow.