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Quinine blocks a calcium‐activated potassium conductance in mammalian enteric neurones
Author(s) -
Cherubinim E.,
North R. A.,
Surprenant A.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10112.x
Subject(s) - afterhyperpolarization , calcium , hyperpolarization (physics) , tetraethylammonium , chemistry , potassium , calcium in biology , tetraethylammonium chloride , potassium channel , myenteric plexus , biophysics , endocrinology , medicine , neuroscience , biology , immunohistochemistry , organic chemistry , nuclear magnetic resonance spectroscopy
Quinine (100 μ m ) abolished the slow calcium‐dependent afterhyperpolarization which occurs after an action potential in some neurones of the guinea‐pig myenteric and submucous plexus. This occurred without any effect on the amplitude or time course of the action potential itself, or on the faster calcium‐independent afterhyperpolarization. Tetraethylammonium did not reduce the slow afterhyperpolarization. Quinine also abolished the hyperpolarization which was evoked by intracellular injection of calcium ions.