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Phenolphthalein stimulates the formation of histamine, 5‐hydroxytryptamine and prostaglandin‐like material by rat jejunum, ileum and colon
Author(s) -
Autore G.,
Capasso F.,
Mascolo N.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10085.x
Subject(s) - phenolphthalein , histamine , ileum , jejunum , prostaglandin , laxative , chemistry , medicine , endocrinology , histaminergic , in vivo , prostaglandin e2 , pharmacology , biology , microbiology and biotechnology , constipation
1 The effects of Phenolphthalein on the formation of histamine, 5‐hydroxytryptamine (5‐HT) and prostaglandin‐like material by rat intestine were examined in vivo.2 Phenolphthalein, in a dose that causes laxation increased the formation of histamine, 5‐HT and prostaglandin‐like material, and indomethacin reduced these increases. 3 The data support the idea that the laxative effect of Phenolphthalein is due to increased intestinal production of prostaglandin, histamine and 5‐HT.