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Endothelium‐dependent relaxation induced by angiotensin II and histamine in isolated arteries of dog
Author(s) -
Toda Noboru
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10079.x
Subject(s) - histamine , mesenteric arteries , endothelium , endocrinology , contraction (grammar) , medicine , vasodilation , acetylcholine , chemistry , angiotensin ii , endothelium derived relaxing factor , artery , blood pressure
1 In helical strips of dog renal and mesenteric arteries pre‐contracted with prostaglandin F 2α (PGF 2α ), endothelium‐dependent relaxations were investigated. Removal of the endothelium was shown histologically by staining with silver nitrate and functionally by testing the inability of acetylcholine to induce arterial relaxations. 2 When the endothelium was removed, relaxation of renal arteries to angiotensin (Ang) II was markedly suppressed, whereas relaxations induced by PGI 2 or isoprenaline were attenuated only slightly. Removal of the endothelium attenuated the relaxant response of mesenteric arteries to histamine but did not significantly alter the response to PGI 2 . 3 Treatment with indomethacin caused an additional attenuation of the relaxant response to histamine or a reversal of the Ang II‐induced relaxation to a contraction in the arterial strips, from which the endothelium had been removed. 4 Relaxation of renal arteries induced by Ang II and of mesenteric arteries induced by histamine is postulated to result from PGI 2 released from the arterial wall. Therefore, it appears that the endothelium is a major site but not the only site responsible for drug‐induced release of PGI 2 .