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Inhibitory effects of centrally acting drugs on the neonatal imprinting of sex differences in the hepatic metabolism of a dimethylated epoxide in the rat
Author(s) -
Finnen Michael J.,
Hassall Kenneth A.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10076.x
Subject(s) - reserpine , chlorpromazine , drug metabolism , metabolism , endocrinology , drug , medicine , pharmacology , morphine , fetus , pregnancy , biology , genetics
1 The effects of the neonatal administration of reserpine, chlorpromazine, phenobarbitone and morphine on the development of sex differences in hepatic drug metabolism in the rat have been investigated. 2 Treatment of neonatal male rats with reserpine or chlorpromazine for the first two weeks post‐partum significantly inhibited the development of sex differences in drug metabolism in adult life. 3 Similar treatment of neonatal female rats with reserpine or chlorpromazine had no effect on the development of hepatic drug metabolism in adulthood. 4 Morphine or phenobarbitone treatment of neonatal rats of either sex had no effect on the development of sex differences in hepatic drug metabolism in adult life.