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Parallel secretion of endogenous 5‐hydroxytryptamine and histamine from mast cells stimulated by vasoactive peptides and compound 48/80
Author(s) -
Carraway R.E.,
Cochrane D.E.,
Granier C.,
Kitabgi P.,
Leeman Eve,
Singer E.A.
Publication year - 1984
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1984.tb10069.x
Subject(s) - histamine , endogeny , vasoactive , secretion , compound 48/80 , vasoactive intestinal peptide , chemistry , endocrinology , mast cell , medicine , pharmacology , biology , biochemistry , immunology , neuropeptide , receptor , degranulation
The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5‐hydroxytryptamine (5‐HT) and histamine. There was no differential effect of any of the secretagogues tested on the secretion of 5‐HT and histamine. Amitriptyline prevented the secretion of histamine in response to stimulation by neurotensin, substance P, somatostatin or compound 48/80 but was without effect on the secretion of endogenous 5‐HT.