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Evidence for pharmacological similarity between α 2 ,‐adrenoceptors in the vas deferens and central nervous system of the rat
Author(s) -
Doxey J.C.,
Gadie B.,
Lane A.C.,
Tulloch I.F.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb11061.x
Subject(s) - vas deferens , rauwolscine , yohimbine , clonidine , endocrinology , agonist , medicine , antagonist , oxymetazoline , alpha 2 adrenergic receptor , alpha (finance) , chemistry , pharmacology , receptor , construct validity , nursing , patient satisfaction
1 Seven α 2 ‐adrenoceptor antagonists with diverse chemical structures have been examined for their effects at α 2 ‐adrenoceptors in the vas deferens and central nervous system of the rat. 2 Antagonist potency assessed against the presynaptic α 2 ‐adrenoceptor agonist action of clonidine in the isolated vas deferens (RX 781094 > AWy 26703 > yohimbine > rauwolscine > piperoxan > mianserin > RS 21361) was highly correlated with the ability of these drugs to displace saturable [ 3 H]‐RX 781094 binding from cerebral cortex membranes. 3 Similarly, antagonist potency in the vas deferens was highly correlated with antagonist activity in reversing the centrally‐mediated mydriasis induced by the selective α 2 ‐adrenoceptor agonist, guanoxabenz, in pentobarbitone‐anaesthetized rats. 4 The results indicate that the presynaptic α 2 ‐adrenoceptors in the vas deferens are pharmacologically similar to characterized these α 2 ‐adrenoceptors in the central nervous system of the rat.