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Studies in rabbits on the disposition and trypanocidal activity of the antitrypanosomal drug, diminazene aceturate (Berenil)
Author(s) -
Gilbert Robert J.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb11058.x
Subject(s) - diminazene , pharmacology , trypanocidal agent , drug , disposition , biology , trypanosomiasis , virology , trypanosoma brucei , biochemistry , psychology , social psychology , gene
1 After intramuscular injection of 3.5 mg kg −1 to rabbits, diminazene aceturate shows biphasic pharmacokinetics with maximum blood and interstitial fluid concentrations occurring after 15 min and 3 h respectively. 2 Seven days after treatment, 40–50% of the dose had been excreted in the urine and 8–20% in faeces. 3 Highest diminazene residues were determined in liver: 7 days after dosage, residues of 40.53 ± 4.00 μg −1 were present, corresponding to 35–50% of the dose. 4 The recommended dose of 3.5 mg kg −1 was not curative for Trypanosoma congolense infections of rabbit but did cause the parasitaemia to become subpatent. A limited prophylactic effect was observed.