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The actions of Paf‐acether (platelet‐activating factor) on guinea‐pig isolated heart preparations
Author(s) -
Benveniste Jacques,
Boullet Cécile,
Brink Charles,
Labat Carlos
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb11052.x
Subject(s) - platelet activating factor , lysophosphatidylcholine , phospholipid , guinea pig , platelet , chemistry , endogeny , pharmacology , atropine , medicine , endocrinology , biochemistry , phosphatidylcholine , membrane
1 Paf‐acether (platelet‐activating factor) is a phospholipid capable of stimulating platelets to release their granular contents and cause platelet aggregation. When Paf‐acether was administered to isolated heart preparations from normal guinea‐pigs there was a significant concentration‐dependent reduction in coronary flow and contractile force. The high concentration of Paf‐acether was equally effective in reducing these cardiac parameters in the presence of atropine. 2 The non‐acetylated Paf‐acether analogue, 2‐lyso Paf‐acether, the enantiomer, and a closely related phospholipid 1,α‐lysophosphatidylcholine palmitoyl, did not affect coronary flow and contractile force, indicating the specificity of Paf‐acether. 3 These data demonstrate a potent effect of Paf‐acether on cardiac function. Whether or not these effects are direct or mediated through generation of endogenous mediators remains to be established.