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Studies on the renin response to vasoactive intestinal polyeptide (VIP) in the conscious rabbit
Author(s) -
Calam John,
Dimaline Rodney,
Peart W. Stanley,
Unwin Robert
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb11043.x
Subject(s) - vasoactive intestinal peptide , propranolol , endocrinology , medicine , plasma renin activity , renin–angiotensin system , vasodilation , stimulation , reflex , heart rate , chemistry , neuropeptide , receptor , blood pressure
Vasoactive intestinal polypeptide (VIP) has been found within the renal cortex and is believed to be a neurotransmitter. Although it produces systemic vasodilatation and renin release, the exact mechanism of the latter response is uncertain. When infused into conscious rabbits, VIP elicits a rise in plasma renin activity (PRA) and an increase in heart rate. The rise in PRA is unaltered by pretreatment with propranolol, but is attenuated by indomethacin. The tachycardia is inhibited by propranolol, but unaffected by indomethacin. We conclude that the renin response to VIP is in part prostaglandin‐dependent and that the heart rate response is due to direct or reflex β‐adrènoceptor stimulation.