Premium
Inhibition of lymphocyte activation by gold sodium thiomalate
Author(s) -
Hopkins Stephen J.,
Jayson Malcolm I.V.,
Zeil Peter
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb11037.x
Subject(s) - gold sodium thiomalate , lymphocyte , lymphocyte activation , sodium , mixed lymphocyte reaction , pharmacology , chemistry , gold compounds , immunology , biochemistry , endocrinology , medicine , immune system , t cell , combinatorial chemistry , rheumatoid arthritis , organic chemistry
1 Activation of lymphoid cells by both T and B cell mitogens was inhibited by gold sodium thiomalate (GST). 2 The action of GST did not appear to be exerted at early stages of lymphocyte activation. 3 Inhibition by GST was sustained throughout 4 days of culture. 4 The inhibitory effect of GST was reduced at low serum concentrations. 5 Sodium thiomalate and sodium chloroaurate were also able to inhibit lymphocyte activation.