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The effects of atropine and secoverine on gastric secretion and motility in the mouse isolated stomach
Author(s) -
Davison J.S.,
Greenwood Beverley,
NajafiFarashah A.,
Read N.W.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb11027.x
Subject(s) - bethanechol , atropine , gastric acid , motility , stomach , secretion , medicine , endocrinology , chemistry , biology , pharmacology , muscarinic acetylcholine receptor , receptor , genetics
1 The isolated perfused stomach of the mouse was used to study the effect of atropine and secoverine on bethanechol‐induced gastric acid secretion and gastric motility. 2 Both atropine and secoverine inhibited cholinergically induced gastric acid secretion and gastric motility. 3 Inhibition of gastric acid secretion by atropine and secoverine occurred at a similar dose‐range (10 −9 and 2 × 10 −9 m ). 4 Secoverine inhibited bethanechol‐induced hypermotility at doses (10 −11 m and above) that were lower than those of atropine (2 × 10 −9 m and above) required to produce this effect. 5 Secoverine, unlike atropine markedly inhibited gastric motility at lower doses than those which affected secretion.