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Cardiovascular responses in rats with glycerol‐induced acute renal failure
Author(s) -
Bowmer C.J.,
Nichols A.J.,
Warren Maxine,
Yates M.S.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb11020.x
Subject(s) - medicine , chronotropic , blood pressure , endocrinology , mean arterial pressure , basal (medicine) , sodium nitroprusside , stimulation , heart failure , norepinephrine , heart rate , nitric oxide , dopamine , insulin
1 Autonomic and cardiovascular function were assessed in rats with glycerol‐induced acute renal failure (ARF). 2 Rats with ARF had significantly lower mean arterial blood pressures and heart rates and significantly elevated plasma noradrenaline concentrations. 3 The chronotropic responses to right cervical sympathetic and vagal stimulation were diminished in rats with ARF. 4 The pressor and depressor responses to noradrenaline and nitroprusside respectively when expressed as a change in mmHg pressure were significantly reduced in rats with ARF when compared to controls. However, when the depressor responses to nitroprusside were expressed as a percentage fall in basal mean arterial pressure, with the exception of the response to a dose of 10 μg kg −1 , there were no significant differences between control and uraemic rats. 5 The present findings show that in the rat, changes in cardiovascular responsiveness occur after a brief period of uraemia which are similar to those observed in patients and rats with chronic renal failure.