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Effects of α‐adrenoceptor antagonists on clonidine‐induced inhibition of insulin secretion by isolated pancreatic islets
Author(s) -
Langer Joachim,
Panten Uwe,
Zielmann Siegfried
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb11014.x
Subject(s) - yohimbine , medicine , endocrinology , prazosin , clonidine , pancreatic islets , insulin , imidazoline receptor , chemistry , alpha 2 adrenergic receptor , biology , antagonist , islet , receptor
1 The effects of clonidine, yohimbine, corynanthine and prazosin on glucose‐induced insulin secretion by incubated or perifused mouse pancreatic islets were investigated. 2 Clonidine (0.1 μ m ) inhibited glucose‐induced insulin secretion alone and in the presence of yohimbine (0.1 μ m ), corynanthine (10 μ m ) or prazosin (1 μ m ). 3 In higher concentrations, yohimbine (1–10 μ m ) antagonized the inhibitory effect of clonidine (0.1 μ m ) upon glucose‐induced insulin secretion by incubated islets and by perifused islets. 4 The results support the view that adrenergic inhibition of insulin secretion is mediated by α 2 ‐adrenoceptors on pancreatic β‐cells.