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Interactions between alinidine and responses to acetylcholine, dopamine and 5‐hydroxytryptamine of specific Helix central neurones
Author(s) -
Bokisch Anita J.,
Walker R.J.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10730.x
Subject(s) - excitatory postsynaptic potential , acetylcholine , dopamine , inhibitory postsynaptic potential , chemistry , medicine , pharmacology , biology , neuroscience , endocrinology
1 Intracellular recordings were made from identified neurones in the brain of the snail, Helix aspersa . The effect of alinidine on the excitatory and inhibitory responses to acetylcholine and dopamine and on the excitatory response to 5‐hydroxytryptamine (5‐HT) was investigated. 2 Alinidine was found to reduce the responses to acetylcholine and 5‐HT and the excitatory response to dopamine but had no effect on the dopamine inhibitory response. pA 2 values were determined for alinidine antagonism to indicate relative potency. The pA 2 values against the excitatory responses of acetylcholine, dopamine and 5‐HT were 5.8, 5.6 and 5.5 respectively. The pA 2 value against acetylcholine inhibition was 3.5. 3 From these studies it is suggested that alinidine interacts preferentially with the sodium ionophore, to a lesser degree with the chloride ionophore and not at all with the potassium ionophore on Helix central neurones.