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Motoneurone excitability after administration of a thyrotrophin releasing hormone analogue
Author(s) -
Clarke K.A.,
Stirk G.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10729.x
Subject(s) - antidromic , depolarization , stimulation , endocrinology , chemistry , medicine , hormone , neuroscience , biology
1 Recordings have been made of motoneurone field potentials at vertebral level L1 to stimulation of the ventral root, in rats anaesthetized with urethane. 2 Injection of thyrotrophin releasing hormone (TRH) analogue RX77368 (2 mg kg −1 ) produced an increase in the amplitude of the field potential within 1 min of injection, reaching peak amplitude of 51–69% above control values 6–12 min after injection; the duration of the elevation was 30–65 min. 3 Arguments are presented which show that this effect is compatible with an RX77368‐induced depolarization of the motoneurone, allowing the antidromic volley to invade more cell bodies.