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Gastric juice electrolyte secretion in conscious dogs with gastric fistulae and its modification by FPL 52694, a mast cell stabilizing agent
Author(s) -
Canfield S.P.,
Curwain B.P.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10715.x
Subject(s) - pentagastrin , histamine , cimetidine , medicine , endocrinology , stimulation , gastric acid , osmotic concentration , chemistry , secretion , mast cell , insulin , hydrochloric acid , immunology , inorganic chemistry
1 Studies have been made of the electrolyte output in the gastric juice of conscious dogs equipped with gastric fistulae during stimulation by intravenous infusion of either pentagastrin (2 μg kg −1 h −1 ), histamine (30 μg kg −1 h −1 ) or insulin (0.1 u kg −1 h −1 ). 2 The mast cell stabilizing agent, FPL 52694 (4.35 mg ml −1 ) was instilled into the stomach for 30 min and caused a marked reduction of H + output, H + concentration and osmotic strength of the juice during stimulation with pentagastrin, histamine, or insulin. There was also a marked increase in the rate of Na + output into the juice. 3 When pentagastrin‐stimulated acid secretion was inhibited by cimetidine (4 μmol kg −1 i.v.) acid output was reduced but there were no sustained changes in ion concentrations, osmolality or Na + output of the type seen following inhibition with FPL 52694. 4 It is concluded that FPL 52694 may have a dual mode of action in this preparation; a direct reduction of the output of hydrochloric acid and a smaller effect to increase gastric NaHCO 3 output leading to a post‐secretory neutralization of the juice.